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My research delves into the core biophysical properties influencing cell behavior by integrating cutting-edge approaches from cell engineering, materials science, and advanced imaging. I examine the fundamental principles of cellular mechanotransduction, a precisely regulated process whose disruption can lead to pathologies such as chronic inflammation and fibrotic conditions. Recent studies have revealed a connection between progressive fibrosis, altered focal adhesion kinase (FAK) activity patterns, and abnormal cell adhesion. Yet the mechanistic link between FAK activity at focal adhesions and fibrosis remains elusive.
By exploring these relationships, I strive to tackle pressing health challenges in musculoskeletal soft tissue regeneration and diseases like progressive fibrosis. My ultimate goal is to create innovative platforms that enhance our understanding of the molecular mechanisms cells utilize in response to biophysical stimuli and how these mechanisms orchestrate physiological systems in healthy and diseased states.